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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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[Systemic sclerosis : A disease with multiple faces].

Caroline Evers1, Jörg Distler2, Oliver Distler3

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Dermatologie (Heidelberg, Germany)
|December 11, 2025
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Summary
This summary is machine-generated.

Systemic sclerosis (SSc) is a rare autoimmune disease affecting skin and organs. Tailored treatment and multidisciplinary collaboration are key for managing its diverse manifestations.

Keywords:
Antifibrotic therapyConnective tissue diseasesImmunosuppression therapyRaynaud diseaseSkin fibrosis

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease.
  • It involves vasculopathy and inflammatory fibrosis affecting skin and internal organs.
  • SSc presents with heterogeneous manifestations, complicating diagnosis and management.

Purpose of the Study:

  • To provide an overview of diverse SSc manifestations.
  • To discuss current treatment approaches for SSc.
  • To emphasize the importance of individualized treatment strategies.

Main Methods:

  • Literature review of SSc manifestations.
  • Summary of current therapeutic options for SSc.
  • Discussion of multidisciplinary care approaches.

Main Results:

  • SSc exhibits a wide range of clinical presentations.
  • Advances in research have expanded therapeutic options.
  • Individualized treatment based on manifestations is crucial.

Conclusions:

  • Effective SSc management requires understanding its diverse manifestations.
  • Tailored treatment strategies are essential for optimal patient care.
  • Close collaboration among various medical specialists is vital for SSc patients.