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Updated: Jan 7, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Co(III)-Catalyzed Three-Component Cascade for the Synthesis of α-Quaternary Acyclic Nitriles via C-H Bond Activation
Priyambada Prusty1, Masilamani Jeganmohan1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.
Abstract:
Herein, we developed a cobalt-catalyzed three-component strategy to synthesize α-quaternary aliphatic nitriles in good yields. This protocol proceeds through the sequential addition of indoles, dienes, and N-cyanosuccinimide. The scope of this method has been extensively explored with various substituted N-pyrimidyl-indoles. Terminally substituted diene and 1,2-disubstituted diene also participated in the reaction. Notably, N-pyridyl-2-pyridones are also compatible with this protocol. The synthesized nitrile product was further converted into a tetrazole derivative. A plausible reaction mechanism is proposed to account for the present transformation.
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