Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Availability and Use of Social Determinants of Health Data in Alliance Gastrointestinal Cancer Clinical Trials.

JCO oncology practice·2026
Same author

A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

Cancer research·2026
Same author

Pancreatic Cancer: Translating Tumor Biology into Actionability.

Cancer discovery·2026
Same author

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors.

bioRxiv : the preprint server for biology·2026
Same author

Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Multimodal blood based proteomic profiling reveals insights into mechanisms of immunotherapy resistance.

Nature communications·2026

Related Experiment Video

Updated: Jan 8, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K

Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer.

Alejandro Jiménez-Sánchez1, Sitara Persad1,2, Akimasa Hayashi3

  • 1Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Cancer Research
|December 11, 2025
PubMed
Summary

Cancer cells adapt to new organs during metastasis, with environment playing a key role in their progression. Understanding this adaptation is crucial for developing new cancer treatment strategies.

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K
Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
06:20

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer

Published on: October 4, 2022

3.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K
Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
06:20

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer

Published on: October 4, 2022

3.7K

Area of Science:

  • Oncology
  • Genomics
  • Systems Biology

Background:

  • Metastasis is the primary cause of cancer-related mortality.
  • Understanding tumor cell adaptation to diverse organ environments is critical for developing anti-metastasis strategies.

Purpose of the Study:

  • To investigate how pancreatic ductal adenocarcinoma cells adapt to different organ microenvironments during metastasis.
  • To identify shared and site-specific gene expression programs in metastatic lesions.

Main Methods:

  • Generation of a single-cell transcriptomic atlas from primary and metastatic tumor samples.
  • Unsupervised archetype analysis to identify gene expression programs.
  • Development of PICASSO, a probabilistic method for inferring clonal phylogeny.
  • Comparison of clonal structure with phenotypic signatures.

Main Results:

  • Identified shared and site-specific gene programs, including lipid metabolism and gastrointestinal programs.
  • Pancreatic cancer cells showed adaptation to local environments with minimal genotypic contribution.
  • Environmental factors significantly influence cancer cell plasticity during metastasis.

Conclusions:

  • Cancer cell adaptation during metastasis is largely driven by environmental influences rather than clonal genotype.
  • This highlights the plasticity of cancer cells and the importance of the tumor microenvironment in metastatic progression.