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Emergence of Dengue Virus Serotype 3, Lineage III_B.3.2, Angola
Emerging Infectious Diseases
|December 11, 2025
Summary
Dengue virus serotype 3 was found in 11.8% of patients in Angola. Genetic analysis suggests it was imported from the Americas and spread locally.
Area of Science:
- Medical Entomology
- Virology
- Epidemiology
Background:
- Dengue virus (DENV) poses a significant global health threat.
- DENV serotype 3 (DENV-3) has re-emerged in various regions.
- Limited data exists on DENV circulation in Angola.
Purpose of the Study:
- To investigate the presence and genetic characteristics of dengue virus in Luanda Province, Angola.
- To determine the origin and transmission dynamics of detected DENV-3 strains.
Main Methods:
- Detection of dengue virus in febrile patients using molecular methods.
- Phylogenetic analysis of viral sequences to determine lineage and origin.
Main Results:
- Dengue virus serotype 3 (DENV-3) was detected in 11.8% (16/136) of febrile patients.
- Genetic analysis identified the DENV-3 lineage as III_B.3.2.
- Evidence suggests introduction from the Americas in late 2022, followed by local transmission.
Conclusions:
- DENV-3 is actively circulating in Luanda Province, Angola.
- The identified lineage points to a probable introduction from the Americas.
- Understanding transmission patterns is crucial for public health interventions.
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