Exploring the link between osteoporosis and stroke risk: An exploratory study based on 2017-2018 NHANES clinical data
Weimin Ren1, Wen Shu1, Shuzhong Huang1
1Department of Orthopedics, Liuzhou People's Hospital (Liuzhou People's Hospital Affiliated to Guangxi Medical University), Liuzhou, Guangxi, China.
Plos One
|December 11, 2025
Summary
Osteoporosis significantly increases stroke risk. Key genes LILRA5, HNRNPL, and AGBL3, along with drugs like Cyclopenthiazide, may offer new interventions for both conditions.
Area of Science:
- Biomedical research
- Genetics
- Pharmacology
Background:
- Osteoporosis and stroke share potential common risk factors and molecular pathways.
- Understanding these links can reveal novel therapeutic targets.
Purpose of the Study:
- To investigate the correlation between Osteoporosis and stroke risk.
- To identify common key genes and potential drug interventions for both diseases using bioinformatics.
Main Methods:
- Clinical data analysis using logistic regression.
- Bioinformatic analysis of gene expression data (GEO database).
- Identification of common genes via differential analysis, LASSO, and ROC curves.
- Drug prediction using the DSigDB database.
Main Results:
- Osteoporosis showed a significant association with increased stroke risk (OR=1.78, p<0.01).
- LILRA5, HNRNPL, and AGBL3 were identified as common key genes for Osteoporosis and stroke.
- These genes demonstrated high diagnostic efficacy for both conditions.
- Cyclopenthiazide, Neostigmine bromide, and R-atenolol were predicted as potential therapeutic agents.
Conclusions:
- A significant positive correlation exists between Osteoporosis and stroke risk.
- LILRA5, HNRNPL, and AGBL3 represent potential common etiological genes.
- Cyclopenthiazide, Neostigmine bromide, and R-atenolol are promising candidates for future therapeutic strategies.
Related Concept Videos
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:31Osteoclasts in Bone Remodeling
3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
380
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
380
01:20Study Designs in Epidemiology
848
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
848
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K