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Related Concept Videos

Brain Waves01:23

Brain Waves

Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...

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Related Experiment Video

Updated: May 12, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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High-Gain Analysis of Postictal sEEG Suppression Identifies Otherwise Invisible Multifrequency Activity, Including

Kameel M Karkar1, Sreekanth Koneru1, Amy Werry-McFarlin1

  • 1Departments of Neurology, University of Texas Health San Antonio, Texas.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|December 11, 2025
PubMed
Summary

High-gain review of stereo-EEG revealed previously undetected high-frequency brain activity during postictal suppression. This finding challenges assumptions about the postictal state and may explain seizure-like behaviors.

Keywords:
PGESPostictal gamma powerPostictal high-frequency oscillationsPostictal semiologyPostictal statePostictal suppression

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Area of Science:

  • Neuroscience
  • Epileptology
  • EEG Analysis

Background:

  • Traditional assumptions suggest minimal or slow brain activity post-seizure.
  • Recent studies indicate higher frequency activity, but its presence during suppression is debated.

Purpose of the Study:

  • To investigate the presence of high-frequency brain activity during postictal suppression using stereo-EEG.
  • To challenge the assumption of absent or slow brain activity in the postictal period.

Main Methods:

  • Stereo-EEG data from six focal to bilateral tonic-clonic seizures were analyzed.
  • Ultra-high gain review (2-5 μV/mm) and time-frequency spectrographic analysis were employed.
  • Gamma band power in the seizure onset zone was quantified and compared to preictal baseline.

Main Results:

  • Ultra-high gain review revealed hidden mixed-frequency and high-frequency oscillatory activity.
  • Significant postictal suppression (18.46 μV) did not completely abolish EEG power, including gamma activity.
  • Persistent ictal discharges were observed under apparent suppression in one case.

Conclusions:

  • Stereo-EEG review at ultra-high gain and spectrographic analysis unmasked low-power, high-frequency activity during postictal suppression.
  • This activity includes intermittent high-frequency oscillations and early sharp activity.
  • The findings challenge the declaration of the postictal state onset and may explain postictal behaviors.