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Role of extracellular matrix in chordoma progression and therapeutic resistance

Chongmin Ren1, Francis J Hornicek2, Andrew E Rosenberg3

  • 1Department of Bone Tumor, The Affiliated Hospital of Qingdao University, No.59 Haier Road, Qingdao, Shandong 266101, China; Department of Orthopedic Surgery, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, Miami, FL 33136, USA.

Critical Reviews in Oncology/Hematology
|December 11, 2025
PubMed

Insights

Chordoma, a rare bone cancer, shows resistance to standard treatments due to its abundant extracellular matrix (ECM). Targeting ECM interactions offers a promising strategy to improve chordoma treatment outcomes.

Area of Science:

  • Oncology
  • Biochemistry
  • Cancer Biology

Background:

  • Chordoma is a rare, malignant bone tumor with poor therapeutic outcomes.
  • It exhibits resistance to chemotherapy and radiotherapy, with underlying mechanisms largely unknown.
  • The tumor microenvironment, particularly the abundant extracellular matrix (ECM), is implicated in chordoma progression and treatment resistance.

Purpose of the Study:

  • To review recent research on the role of the extracellular matrix (ECM) in chordoma.
  • To highlight specific ECM molecules and their functions in chordoma progression and therapeutic resistance.
  • To discuss potential therapeutic strategies targeting ECM and associated signaling pathways in chordoma management.

Main Methods:

  • Literature review of recent studies on chordoma and its extracellular matrix.
  • Analysis of the roles of distinct ECM molecules in chordoma.
  • Identification of key factors and signaling pathways regulating ECM in chordoma.

Main Results:

  • The abundant ECM in chordoma significantly influences tumor progression and prognosis.
  • Specific ECM components play critical roles in mediating resistance to conventional therapies.
  • Disrupting tumor-ECM interactions presents a viable therapeutic avenue.

Conclusions:

  • Targeting the extracellular matrix (ECM) and its interactions holds significant therapeutic potential for chordoma.
  • Further research and clinical trials focusing on ECM-targeted therapies are warranted.
  • Advancing chordoma treatment may be achieved by understanding and manipulating the tumor-ECM axis.
Keywords:
ChordomaECM targeted therapiesExtracellular matrix (ECM)Therapy resistance

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