Cardiovascular complications in children with Down syndrome and sleep disordered breathing
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View abstract on PubMed
Summary
This summary is machine-generated.Children with Down syndrome (DS) and sleep-disordered breathing (SDB) exhibit cardiopulmonary dysfunction. Early detection and multimodal treatments are vital for reducing cardiovascular risk in this population.
Area Of Science
- Pediatric Cardiology
- Sleep Medicine
- Genetics
Background
- Children with Down syndrome (DS) have anatomical and neuromuscular differences increasing sleep-disordered breathing (SDB) risk.
- SDB in children can lead to significant cardiovascular complications.
Purpose Of The Study
- To conduct a scoping review of cardiovascular complications in children with DS and SDB.
- To identify knowledge gaps for future research and clinical practice.
Main Methods
- Systematic scoping review adhering to PRISMA-ScR guidelines.
- Searches across Embase, Scopus, and MEDLINE databases.
- Included studies focused on children (1-18 years) with DS and SDB reporting cardiovascular outcomes.
Main Results
- Seven studies with 1,437 participants were analyzed.
- Children with DS and SDB demonstrated blunted autonomic responses, impaired heart rate and blood pressure dipping, and increased hypoxia.
- Early signs of left ventricular diastolic dysfunction and bi-ventricular remodeling were observed.
Conclusions
- A link exists between SDB, DS, and cardiopulmonary end-organ dysfunction, indicating elevated clinical risk.
- Continuous cardiac monitoring and advanced physiologic measures are essential.
- Multimodal airway obstruction treatments may mitigate long-term cardiovascular risk.
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