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Programmable Assembly of Multistranded Helices in Water.

Dimitri Delcourt1, Reguram Arumugaperumal1, Prachi Verma1

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|December 11, 2025
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Summary
This summary is machine-generated.

Researchers created molecular strands that self-assemble into specific helical structures. The sequence of these strands controls whether they form a single helix or dynamic assemblies, paving the way for adaptive materials.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Sequence-specific conformational changes are vital for biological processes but challenging to replicate synthetically.
  • Controlling the dynamic behavior of molecular assemblies is key for advanced materials.

Purpose of the Study:

  • To develop a simple method for encoding structural and dynamic information into molecular strand sequences.
  • To demonstrate programmable self-assembly of oligo(m-phenylene ethynylene) strands.

Main Methods:

  • Designing oligo(m-phenylene ethynylene) strands with hydrophobic phenylene and charged pyridinium residues.
  • Investigating self-assembly into double and triple helices based on sequence.
  • Controlling helical state transitions using concentration, temperature, and anionic molecules.

Main Results:

  • The primary sequence of molecular strands reliably dictates the formation of specific helical structures (e.g., double helix).
  • Dynamic assemblies, including double and triple helices, can be formed and interconverted.
  • External stimuli like concentration, temperature, and anions modulate the helical state transitions.

Conclusions:

  • A minimal sequence-based design strategy enables programmable control over supramolecular helix formation and dynamics.
  • This approach provides a foundation for creating adaptive supramolecular systems with tunable structure and function.