Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence
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View abstract on PubMed
Summary
This summary is machine-generated.Children born preterm (≤32 weeks gestational age) face higher risks of adolescent obesity and hypertension. Rapid weight gain from birth is a key predictor for these conditions, alongside elevated triglycerides and leptin.
Area Of Science
- Pediatric Endocrinology
- Cardiovascular Health
- Metabolic Disorders
Background
- Childhood overweight/obesity is linked to adult cardiovascular risk.
- Preterm birth (PTB) is a known risk factor for childhood overweight/obesity.
- Longitudinal studies on PTB, childhood obesity, and adipokine/lipid profiles are limited.
Purpose Of The Study
- To investigate the long-term effects of preterm birth on cardiovascular risk factors in early adolescence.
- To examine the association between weight gain velocity, adipokines, lipids, and hypertension in preterm-born children.
- To identify potential predictors for overweight/obesity and elevated blood pressure in this population.
Main Methods
- Reenrolled 62 children born ≤32 weeks gestational age (GA) at 10-13 years old.
- Measured anthropometric indices, systolic blood pressure (SBP), serum lipids, and adipokines.
- Matched with 62 term-born controls using NHANES data.
Main Results
- Preterm-born children had significantly higher SBP (48% vs. 12%) and dyslipidemia (elevated triglycerides and LDL).
- Weight gain velocity from birth to adolescence predicted overweight/obesity and elevated SBP in preterm-born children.
- Serum leptin and leptin:adiponectin ratio were significantly elevated in preterm-born children, correlating with obesity and hypertension.
Conclusions
- Early adolescent Hispanic children born ≤32 weeks GA exhibit increased risks for obesity, hypertension, dyslipidemia, and elevated adipokines.
- Weight gain velocity is a potential tool for identifying at-risk children born preterm.
- Findings highlight the need for early monitoring and intervention in preterm populations to mitigate long-term cardiovascular risks.
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