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Updated: May 5, 2026

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Published on: December 31, 2015

MicroSort® sperm sorting causes no increase in major malformation rate.

Donald P Marazzo^1,2,3, David Karabinus¹, Lawrence A Johnson⁴

¹Genetics and IVF Institute, 3015 Williams Drive, Fairfax, VA 22031, USA.

Reproduction, Fertility, and Development

|December 12, 2025

Summary

This summary is machine-generated.

MicroSort sperm sorting is safe, with no increased risk of major malformations in infants. This study monitored pregnancies conceived via sperm sorting from conception to one year of life, finding comparable outcomes to conventional methods.

Keywords:

IVF X-linked diseases assisted reproductive technologies birth defects family balancing genetic disease prevention intracytoplasmic sperm injection sexual selection

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Area of Science:

Reproductive Medicine
Genetics
Perinatology

Background:

Sperm sorting technologies aim to improve reproductive outcomes.
Assessing the safety of sperm sorting, specifically MicroSort, is crucial for clinical application.
Previous data on malformation rates after sperm sorting is limited.

Purpose of the Study:

To evaluate the safety of MicroSort sperm sorting.
To monitor major malformations in infants and fetuses conceived using sorted sperm.
To compare malformation rates in MicroSort pregnancies with control groups.

Main Methods:

Prospective data collection from conception through one year of infant life.
Comprehensive ascertainment of major malformations in fetuses, stillbirths, and live-born infants.
Comparison of MicroSort pregnancy outcomes with published data from assisted reproduction and general populations.

Main Results:

The rate of major malformations in MicroSort pregnancies conceived via IVF was 7.8%, not significantly different from assisted reproductive technology controls (8.3-9.2%).
The rate of major malformations in MicroSort pregnancies conceived via IUI was 6.0%, not significantly different from non-assisted reproductive technology controls (4.6-6.9%).
No association was found between MicroSort sperm sorting and major malformations.

Conclusions:

MicroSort sperm sorting is a safe technology.
There is no increased risk of major malformations in infants conceived using MicroSort sperm.
Further research can build upon these findings to support assisted reproductive technologies.