Related Experiment Video
Updated: Jan 8, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
A Pathway for Improving Performance and Interpretation of Strain in a Pediatric Echocardiography Laboratory
Shivani Patel1,2, Nazia Husain1,2, Jennifer Acevedo1
1Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Insights
Implementing a structured pathway improved global longitudinal strain (GLS) reporting and accuracy in pediatric echocardiography. This ensures reliable assessment of heart function in children at risk for cardiotoxicity.
Area of Science:
- Pediatric Cardiology
- Cardiac Imaging
- Echocardiography
Background:
- Echocardiographic assessment of myocardial deformation is crucial for evaluating left ventricular systolic function in pediatric patients.
- Accurate and reproducible strain data are essential for clinical utility in pediatric echocardiography labs.
- This study details an institutional pathway for successful implementation of strain analysis.
Purpose of the Study:
- To describe the institutional experience and pathway for implementing global longitudinal strain (GLS) analysis in pediatric echocardiography.
- To improve the quality and accuracy of GLS performance and reporting in children at risk for cardiotoxicity.
Main Methods:
- Utilized plan-do-study-act cycles from 2016 onwards, including protocol development, education, and equipment/software updates for GLS.
- Reviewed echocardiograms from 2019-2023 for children at risk of chemotherapy-related cardiotoxicity (CTRCD).
- Assessed the percentage of echocardiograms with performed and reported GLS, evaluating accuracy.
Main Results:
- GLS reporting increased from 39% in 2019 to 76% in 2023; accuracy improved from 57% to 72% (p < 0.001).
- Inaccurate GLS was attributed to poor image quality (24%), border tracing errors (45%), or both (21%).
- Reporting of GLS improved significantly with on-cart automation, easier post-processing, and iterative education.
Conclusions:
- Administrative, technological, and educational interventions are key to establishing consistent, high-quality GLS performance and accurate reporting in pediatric echocardiography.
- Successful implementation pathways are vital for reliable myocardial deformation assessment in pediatric cardiology.
Background:
Echocardiographic quantification of myocardial deformation is a valuable tool to assess left ventricular systolic function in children at risk for systolic dysfunction. Since clinical utility is dependent on accurate and reproducible data, pediatric echo labs should establish a process to ensure high quality strain performance and interpretation. We describe our institutional experience of a successful strain implementation pathway.
Methods:
Starting in 2016, various plan-do-study-act cycles were implemented, including a comprehensive echocardiography function protocol, knowledge and skill-based education, updated equipment and software to optimize acquisition, reporting, and billing for global longitudinal strain (GLS). We reviewed a sample of echocardiograms annually from 2019 to 2023 on children at risk for chemotherapy related cardiotoxicity (CTRCD). We calculated the percentage of echocardiograms that performed and reported GLS, reviewing for accuracy.
Results:
From 2019 to 2023, 685 echocardiograms were reviewed. GLS reporting increased from 39% in 2019 to 76% in 2023 and accuracy improved from 57% to 72% (p < 0.001). Reasons for inaccurate GLS included poor 2D image quality (24%), endocardial border tracing errors despite good image quality (45%) or both (21%). In almost half the studies where GLS was measurable but not reported [99/214; 46%], GLS had not been performed on the echo cart. Reporting of GLS improved from 27% in 2019 to 66% in 2023 with on-cart automation and easier post-processing; and other interventions, including iterative education.
Conclusions:
Implementation of administrative, technological, and educational interventions helps to establish a pathway of consistent, high-quality performance and accurate reporting of GLS in pediatric echocardiography labs.
More Related Videos
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
Related Concept Videos
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...