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Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Jan 8, 2026

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
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Application of transcriptomics techniques in skin cancer.

Yuhan Ma1,2, Fangfang Wang1,2, Suling Xu1

  • 1Department of Dermatology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Frontiers in Oncology
|December 12, 2025
PubMed
Summary

Transcriptomics, a powerful tool for analyzing gene expression, is advancing skin cancer research. This technology helps uncover complex mechanisms, identify therapeutic targets, and improve skin cancer treatment strategies.

Keywords:
basal cell carcinomamelanomasingle-cell transcriptomicsskin cancerspatial transcriptomicssquamous cell carcinoma of the skintranscriptomics

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Skin cancer is a prevalent malignancy with increasing mortality.
  • Transcriptomics offers insights into complex disease mechanisms and the tumor microenvironment.
  • Next-generation sequencing technologies have accelerated transcriptomic research.

Purpose of the Study:

  • To review the development of transcriptomics technology.
  • To summarize transcriptomic research progress in skin cancer.
  • To enhance understanding of skin cancer development mechanisms.

Main Methods:

  • Analysis of differentially expressed genes using transcriptomics.
  • Review of existing literature on transcriptomics in skin cancer research.
  • Exploration of tumor microenvironment and drug resistance mechanisms.

Main Results:

  • Transcriptomics provides crucial tools for skin cancer research.
  • Identified complex gene expression patterns in skin cancer.
  • Highlighted transcriptomics' role in understanding tumor biology.

Conclusions:

  • Transcriptomics is vital for advancing skin cancer understanding.
  • Potential for identifying novel therapeutic targets in skin cancer.
  • Offers new insights for optimizing clinical treatment strategies for skin cancer.