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Exploratory spatial transcriptomic profiling of peritumoral Th2 immune polarization in HPV-positive oropharyngeal

Naohiro Wakisaka1,2, Makiko Moriyama-Kita2, Satoru Kondo2

  • 1Department of Otorhinolaryngology, NHO Kanazawa Medical Center, Kanazawa, Japan.

Frontiers in Oncology
|December 12, 2025
PubMed
Abstract

Keywords:
HPV-positive oropharyngeal cancerTh2 immunityeosinophils and mast cellsestrogen signalinglymphatic metastasispalatine tonsilspatial transcriptomicstumor immune microenvironment

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