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Case Report: Hypertrophic cardiomyopathy meets left ventricular hypertrabeculation: from mixed cardiomyopathy to

Yang Li1, Yang Liu1, Xiaofei Zheng2

  • 1Department of Cardiology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.

Frontiers in Cardiovascular Medicine
|December 12, 2025
PubMed

Insights

This case report details a patient with heart failure and embolic events, diagnosed with hypertrophic cardiomyopathy and left ventricular non-compaction. The rare co-occurrence required updated diagnosis per European Society of Cardiology guidelines.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • A young male presented with worsening heart failure and recurrent embolic events.
  • Previous diagnosis of hypertrophic cardiomyopathy (HCM) and left ventricular systolic dysfunction, with irregular treatment.
  • Echocardiography and cardiac MRI revealed left ventricular myocardial non-compaction combined with HCM.

Keywords:
cardiac MRcardiomyopathyheart failurehypertrophic cardiomyopathyleft ventricular non-compaction/hypertrabeculation

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