Related Experiment Video
Updated: Jan 8, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Mesalazine vs. IBS-D: Examining its impact on patient symptoms & stool calprotectin levels: A randomized
Mohammad Hossein Somi1, Masoud Faghieh Dinavari1, Behnam Sajedi2
1Liver and Gastrointestinal Diseases Research Center, Tabriz University of medical sciences, Tabriz, Iran.
Background:
Irritable bowel syndrome (IBS) is the most common disorder of the gastrointestinal system. The study aimed to determine the effect of Mesalazine prescription on patients' symptoms and level of fecal calprotectin in patients with IBS with predominant diarrhea and high fecal calprotectin.
Methods:
We conducted a double-blinded randomized clinical trial with 90 patients aged 18 to 45. These patients were selected from referrals to the gastroenterology clinic. They were evenly divided into two groups: the Mesalazine group, with an average age of 35.4, and the placebo group, with an average age of 36. The patients in both groups were then monitored for 8 weeks. There were no differences in the distribution of sexes between the two groups.
Results:
In comparison between before and after Mesalazine therapy in our patients marked a statistically significant effect on the quality of life variables (p<0.05), patient's level of pain (p<0.05), abdominal distension (p<0.05), and calprotectin level (p<0.05) compared to before Mesalazine in patients studied, which showed the effectiveness of this treatment. However its effect on stool form was not significant (P=0.11).
Conclusion:
Comparing the two groups after the intervention, the quality of life in patients treated with Mesalazine was significantly higher than in patients of the placebo group. The number of defecations in patients treated with Mesalazine was significantly lower than in patients of placebo groups. Abdominal distention and calprotectin levels were significantly lower in these patients than in patients of the placebo group.
More Related Videos
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
08:34Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...