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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

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Related Experiment Video

Updated: Jun 18, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

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Elevated DUOX2 levels correlate with necrotizing enterocolitis development.

Wenqiang Sun1,2, Xue Liu1,2, Jiahui Huang1,2

  • 1Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.

Frontiers in Cellular and Infection Microbiology
|December 12, 2025
PubMed
Summary
This summary is machine-generated.

Dual Oxidase 2 (DUOX2) is significantly elevated in necrotizing enterocolitis (NEC) tissues and serum. High DUOX2 levels are a risk factor for NEC in preterm infants, aiding in diagnosis.

Keywords:
biomarkerdual oxidase 2immunitynecrotizing enterocolitisserum

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Area of Science:

  • Biochemistry
  • Immunology
  • Neonatal Medicine

Background:

  • Neonatal necrotizing enterocolitis (NEC) is a severe intestinal disease affecting preterm infants.
  • Immune responses and redox reactions are implicated in NEC pathophysiology.
  • The precise molecular mechanisms underlying NEC require further elucidation.

Purpose of the Study:

  • To investigate the role of Dual Oxidase 2 (DUOX2) in neonatal necrotizing enterocolitis (NEC).
  • To assess DUOX2 expression in NEC tissues and serum of preterm infants.
  • To evaluate DUOX2 as a potential biomarker for NEC diagnosis and risk.

Main Methods:

  • Identified DUOX2 as upregulated in NEC intestinal tissues.
  • Performed Gene Ontology (GO) enrichment and immune infiltration analysis.
  • Utilized a nested case-control design to analyze serum DUOX2 protein levels in preterm infants.

Main Results:

  • DUOX2 was significantly overexpressed in NEC tissues, predicting NEC occurrence (AUC=0.844).
  • Differentially expressed genes were linked to redox reactions, including reactive oxygen species (ROS).
  • Elevated serum DUOX2 levels were identified as a risk factor for NEC (AUC=0.809), correlating with clinical markers.

Conclusions:

  • Elevated DUOX2 expression is significantly associated with NEC development in preterm infants.
  • DUOX2 shows potential as a diagnostic biomarker for NEC.
  • Further research into DUOX2's role may offer therapeutic insights.