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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Association between vascular aging and cardiovascular-kidney-metabolic syndrome

Shuyi Zeng1, Henghua Cui1, Wang Liao1

  • 1Department of Cardiology, The First People's Hospital of Yulin, the Sixth Affiliated Hospital of Guangxi Medical University, Yulin, China.

Frontiers in Endocrinology
|December 12, 2025
PubMed

Insights

Elevated estimated pulse wave velocity (ePWV) is linked to higher Cardiovascular-Kidney-Metabolic syndrome (CKM) risk, especially in young adults. This highlights ePWV as a key marker for CKM progression and cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Diseases

Background:

  • Cardiovascular-Kidney-Metabolic syndrome (CKM) involves complex interactions between metabolic factors, chronic kidney disease (CKD), and cardiovascular health.
  • CKM increases susceptibility to organ dysfunction and adverse cardiovascular events.
  • Reliable markers are crucial for effective CKM management.

Purpose of the Study:

  • To investigate the association between estimated pulse wave velocity (ePWV) and mortality and prognosis in patients with CKM.
  • To assess ePWV as a potential biomarker for CKM progression and cardiovascular risk.

Main Methods:

  • Analysis of 14,372 participants from the National Health and Nutrition Examination Survey (NHANES) (2005-2018).
  • Utilized weighted logistic regression and Cox proportional hazards models to examine the relationship between ePWV and CKM risk.
  • Employed bootstrap sampling for mediation analysis of the Triglyceride-Glucose (TyG) index and external validation using a separate cohort.

Main Results:

  • A nonlinear positive association was found between ePWV and CKM (P < 0.01), most pronounced in young adults (20-40 years).
  • Higher ePWV was significantly associated with worse survival rates.
  • The TyG index mediated 25.23% of the ePWV-CKM association; an ePWV threshold of 8.52 for CKM Stage 4 was validated.

Conclusions:

  • Elevated ePWV is nonlinearly associated with increased CKM risk, particularly in younger populations.
  • ePWV serves as a valuable indicator for arterial stiffness and CKM progression.
  • Findings offer insights for managing arterial stiffness and preventing early cardiovascular disease in high-risk individuals.
Abstract

Keywords:
cardiorenal syndromescardiovascular–kidney–metabolic syndromemetabolic syndromepulse wave velocityvascular stiffness

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