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Updated: Jan 8, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
MOF MIL-53(Al) catalyzed hydroacylation of azodicarboxylates: sustainable catalyst for heterogeneous acylhydrazide
Reynier Báez1,2, Lucas Marchini2, José A C Delgado2
1Department of Organic Chemistry, Faculty of Chemical Sciences, Universidad de Concepción Concepción 4130000 Chile cjimenez@udec.cl.
Abstract:
This study reports one of the few examples of acylhydrazide synthesis catalyzed by the metal-organic framework (MOF) MIL-53(Al) via the aldehyde C(sp2)-H hydrazidation reaction. The material exhibited high catalytic performance, displaying a broad substrate scope and affording yields of up to 97%. The catalyst retained its structural integrity and activity for at least four consecutive cycles, with no significant metal leaching. Notably, MIL-53(Al) was synthesized from waste-derived materials and thoroughly characterized to confirm its crystallinity, structural integrity, and porosity - features essential to its catalytic function. This work demonstrates the potential of upcycled MIL-53(Al) as a stable, sustainable, and low-cost heterogeneous catalyst for the synthesis of valuable acylhydrazides, offering an attractive alternative to conventional systems that rely on toxic metal promoters.
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