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DMFF-Net: a multi-scale feature fusion network based on DeepLabV3 for skin lesion segmentation
Tao Jiang1, Shange Wang1, Lin Xu1
1School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in Medicine
|December 12, 2025
Summary
DMFF-Net, a novel deep learning model, significantly enhances skin lesion segmentation accuracy for early skin cancer detection. This advanced network effectively overcomes challenges like unclear boundaries and low contrast, improving diagnostic tools.
Area of Science:
- Medical Image Analysis
- Computer-Aided Diagnosis
- Dermatology
Background:
- Precise skin lesion segmentation is vital for early skin cancer detection.
- Challenges include unclear boundaries, low contrast, and varied lesion shapes.
- Existing methods struggle with complex segmentation tasks.
Purpose of the Study:
- To propose DMFF-Net, a multi-scale, multi-attention feature fusion network.
- To improve the accuracy of skin lesion segmentation in medical images.
- To address limitations of current segmentation techniques.
Main Methods:
- Developed DMFF-Net based on DeepLabV3 architecture.
- Integrated Global Grid Coordinate Attention Module (GGCAM) for spatial-channel feature fusion.
- Employed Multi-Scale Depthwise Separable Dilated Convolution (MDSDC) for robust multi-scale feature extraction.
- Utilized Mid-High Level Feature Fusion (MHLFF) to refine features and suppress noise.
Main Results:
- DMFF-Net achieved superior performance on ISIC 2016, 2017, 2018, and PH2 datasets.
- Reported MIoU values of 89.31%, 91.47%, 86.93% on ISIC datasets.
- Achieved high accuracy (up to 97.33%) and F1 scores (up to 96.93%) demonstrating effectiveness.
Conclusions:
- DMFF-Net significantly improves skin lesion segmentation accuracy.
- The network's multi-scale fusion and attention mechanisms preserve spatial details and enhance feature representation.
- DMFF-Net shows potential as a valuable tool for skin lesion diagnosis and medical image segmentation research.
