Related Experiment Video
Updated: Jan 7, 2026
Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
Adult Acute Myeloid Leukaemia With DDX3X::MLLT10: A Rare Entity With Significant Unmet Clinical Needs
Jun Yen Ng1,2, Arun Sr2, Maansi Joshi2
1School of Medicine and Psychology College of Science and Medicine Australian National University Canberra Australia.
Abstract:
DDX3X::MLLT10¸ which arises from t(X;10)(p11.4;p12.31), is infrequently observed in adult acute myeloid leukaemia (AML). The clinical and pathological characteristics are also not well characterised, detailed in only two cases published to date. This third case reports the fusion gene in a 27-year-old female with acute myelomonocytic leukaemia (AMML) with refractoriness to multiple lines of chemotherapy. Collectively, these cases highlight the genomic heterogeneity of this rare entity, as well as significant unmet clinical needs due to the poor prognosis and chemoresistance observed. These findings may inform future iterations of AML classification and prognostication in adults.
