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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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Cronkhite-Canada Syndrome With Multiple Mesenteric Lymphadenopathy: A Case Report.

Takashi Nishino1, Chikamasa Ichita1, Akiko Sasaki1

  • 1Gastroenterology Medicine Center Shonan Kamakura General Hospital Kamakura Kanagawa Japan.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|December 12, 2025
PubMed
Summary

Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal disorder. This case highlights that mesenteric lymphadenopathy in CCS can improve with corticosteroid treatment.

Keywords:
Cronkhite–Canada syndromeautoimmune mechanismmesenteric lymphadenopathypolyposis

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Area of Science:

  • Gastroenterology
  • Rare Diseases
  • Dermatology

Background:

  • Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary disorder.
  • It is characterized by gastrointestinal polyps and ectodermal changes.
  • Delayed diagnosis or treatment can lead to a high mortality rate (up to 50%).

Purpose of the Study:

  • To report a case of Cronkhite-Canada syndrome (CCS).
  • To highlight the association between CCS and mesenteric lymphadenopathy.
  • To demonstrate the efficacy of corticosteroid therapy in managing mesenteric lymphadenopathy in CCS.

Main Methods:

  • A case study of a 78-year-old Japanese woman.
  • Clinical presentation: diarrhea, dysgeusia, anorexia, weight loss, alopecia, nail atrophy, hyperpigmentation.
  • Diagnostic tools: Abdominal CT scan and endoscopic examination.
  • Treatment: Prednisolone (30 mg/day).

Main Results:

  • The patient presented with typical CCS symptoms and findings.
  • Abdominal CT revealed enlarged mesenteric lymph nodes.
  • Endoscopy showed numerous hyperplastic polyps throughout the gastrointestinal tract.
  • One month of prednisolone treatment led to a reduction in mesenteric lymph node size.

Conclusions:

  • Mesenteric lymphadenopathy is an uncommon but potential manifestation of CCS.
  • Corticosteroid therapy, such as prednisolone, can be effective in reducing mesenteric lymphadenopathy in CCS patients.
  • Early diagnosis and appropriate treatment are crucial for improving outcomes in CCS.