Cronkhite-Canada Syndrome With Multiple Mesenteric Lymphadenopathy: A Case Report

Area of Science:

• Gastroenterology
• Rare Diseases
• Dermatology

Background:

• Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary disorder.
• It is characterized by gastrointestinal polyps and ectodermal changes.
• Delayed diagnosis or treatment can lead to a high mortality rate (up to 50%).

Purpose of the Study:

• To report a case of Cronkhite-Canada syndrome (CCS).
• To highlight the association between CCS and mesenteric lymphadenopathy.
• To demonstrate the efficacy of corticosteroid therapy in managing mesenteric lymphadenopathy in CCS.

Main Methods:

• A case study of a 78-year-old Japanese woman.
• Clinical presentation: diarrhea, dysgeusia, anorexia, weight loss, alopecia, nail atrophy, hyperpigmentation.
• Diagnostic tools: Abdominal CT scan and endoscopic examination.
• Treatment: Prednisolone (30 mg/day).

Main Results:

• The patient presented with typical CCS symptoms and findings.
• Abdominal CT revealed enlarged mesenteric lymph nodes.
• Endoscopy showed numerous hyperplastic polyps throughout the gastrointestinal tract.
• One month of prednisolone treatment led to a reduction in mesenteric lymph node size.

Conclusions:

• Mesenteric lymphadenopathy is an uncommon but potential manifestation of CCS.
• Corticosteroid therapy, such as prednisolone, can be effective in reducing mesenteric lymphadenopathy in CCS patients.
• Early diagnosis and appropriate treatment are crucial for improving outcomes in CCS.