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Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Selenium supplementation in individuals with newly diagnosed Graves' hyperthyroidism: a double-blind, multi-centre

Per K Cramon1, Kristian H Winther2, Victor B Boesen3

  • 1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

European Thyroid Journal
|December 12, 2025
PubMed
Summary
This summary is machine-generated.

Selenium supplementation did not improve remission rates or quality of life in patients with Graves

Keywords:
Graves’ diseaseGraves’ hyperthyroidismThyPROpragmatic trialquality of lifeselenium

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Clinical Trials

Background:

  • Graves' hyperthyroidism is an autoimmune condition affecting the thyroid gland.
  • Selenium is a trace element with antioxidant properties, and its role in Graves' disease is under investigation.
  • Quality of life (QoL) is a crucial outcome measure in chronic conditions like Graves' hyperthyroidism.

Purpose of the Study:

  • To evaluate the efficacy of selenium supplementation versus placebo in improving remission rates for Graves' hyperthyroidism.
  • To assess the impact of selenium on the quality of life (QoL) in patients with Graves' hyperthyroidism.

Main Methods:

  • A double-blinded, placebo-controlled, multi-center trial (Graves' Selenium Supplementation - GRASS trial) involving 430 participants.
  • Participants received daily 200 μg selenium or placebo for 24-30 months alongside standard antithyroid drugs (ATD).
  • Remission was defined by sustained normal thyroid hormone levels and absence of ATD use; QoL was measured using the ThyPRO instrument.

Main Results:

  • No significant difference in non-remission rates between the selenium (54.6%) and placebo (53.3%) groups (OR = 1.0; P = 0.98).
  • Selenium supplementation showed no beneficial effect on any quality of life (QoL) scale assessed by ThyPRO.
  • Thyrotropin receptor antibody levels remained similar between groups at follow-up.

Conclusions:

  • Daily selenium supplementation, as an add-on to standard antithyroid drugs, did not demonstrate any benefits for newly diagnosed Graves' hyperthyroidism.
  • The GRASS trial findings do not support the use of selenium supplementation for managing Graves' hyperthyroidism.
  • Selenium does not appear to influence remission rates or quality of life in this patient population.