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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
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Mineralizing Elastin-Like Protein Microgels.

Ieva Sapjanskaite1,2, Abshar Hasan1,2,3, José Carlos Rodríguez-Cabello4

  • 1School of Pharmacy, University of Nottingham, Nottingham, UK.

Journal of Biomedical Materials Research. Part A
|December 12, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed injectable elastin-like recombinamer (ELR) microgels for bone regeneration. These microgels facilitate organized apatite mineralization and show promise for hard tissue repair applications.

Keywords:
elastin‐like recombinamershydroxyapatitemicrogelsorganized mineralizationprotein‐based biomineralization

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Mineralization

Background:

  • Mineralized tissues like bone and enamel rely on organic-inorganic interactions.
  • Elastin-like recombinamers (ELRs) are used in tissue engineering but not yet as microgels.
  • Organized mineralization is key for biological tissues and engineered materials.

Purpose of the Study:

  • To develop injectable ELR microgels for organized apatite mineralization.
  • To explore ELR microgels as scaffolds for hard tissue repair.
  • To assess the mineralization capacity and biocompatibility of ELR microgels.

Main Methods:

  • Fabrication of injectable ELR microgels via water-in-oil emulsification.
  • Mineralization of ELR microgels to form apatite-like crystals.
  • Characterization using SEM, TEM, FTIR, XRD, and cell viability assays.

Main Results:

  • Successfully fabricated injectable ELR microgels capable of organized mineralization.
  • Achieved approximately 20 wt% mineral content with hydroxyapatite structure.
  • Demonstrated low cytotoxicity (>90% hMSC viability) and enhanced osteogenic potential (40% ALP increase).

Conclusions:

  • ELR microgels offer a versatile platform for mineralized tissue engineering.
  • The microgel format enhances surface area and handling for applications like injectable scaffolds and 3D bioprinting.
  • ELR microgels show significant potential for advancing hard tissue repair strategies.