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Updated: Jan 8, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Rhodium-Catalyzed Regioselective C-H Amidation of Benzaldehydes with Dioxazolones: Weakly Coordinating Aldehyde as a
Jing-Wen Jia1, Juan Fan1, Xiao-Zuan Chen1
1Key Laboratory of Syngas Conversion of Shaanxi Province, Key Laboratory for Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
Abstract:
A rhodium-catalyzed C-H amidation of ortho/para-substituted benzaldehydes with dioxazolones has been developed to afford meta-substituted aromatic amides in moderate to good yields. This transformation proceeds via weakly coordinating aldehyde-directed ortho-C-H functionalization and concomitant decarbonylation processes. The aldehyde group notably serves as a unique traceless directing group that effectively controls the regioselectivity of the reaction. This protocol features operational simplicity and avoids the need for a transient directing group.
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