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Updated: Jan 8, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

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DEC1 regulates human β cell functional maturation and circadian rhythm

Sam Preza1, Bliss Zheng2, Zihan Gao1

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Chronobiology and Sleep Institute, and Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Cell Reports
|December 12, 2025
PubMed

Keywords:
3D organoidsCP: developmental biologyCP: metabolismSC-β cell maturationcell replacement therapycircadian clockglucose-stimulated insulin secretionmetabolic synchronizationβ-cell energetics

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