Automatic generation of a digital twin for continuous antibody capture
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.We developed an automated procedure to create and calibrate digital twins for monoclonal antibody purification. This digitalization enhances process efficiency and sustainability, reducing costs and accelerating drug discovery.
Area Of Science
- Biotechnology
- Chemical Engineering
- Process Automation
Background
- Digitalization offers enhanced efficiency and sustainability in monoclonal antibody downstream processing.
- Digital twins provide process insights and optimization but are challenging to create.
- Automated generation and calibration of digital twins are needed for wider adoption.
Purpose Of The Study
- To develop an automated procedure for generating and calibrating digital twins for chromatography.
- To demonstrate the utility of digital twins for process optimization in monoclonal antibody purification.
- To reduce the time and effort required for digital twin acquisition.
Main Methods
- Automatic generation of a digital twin based on chromatography setup configuration.
- Automated execution of a calibration procedure involving experiments and simulations.
- Application of the digital twin for optimizing yield, resin utilization, and column capacity variations.
Main Results
- Experimental validation showed a 0.6% difference in yield and resin utilization compared to simulation.
- Optimization for reduced column capacity increased resin utilization by 1.2% with 99.8% yield.
- The automated procedure efficiently generated and calibrated a functional digital twin.
Conclusions
- The developed procedure enables efficient digital twin generation and calibration for monoclonal antibody downstream processing.
- Integrating digitalization through digital twins can lower production costs and improve sustainability.
- This work represents a significant step towards automated and optimized biopharmaceutical manufacturing.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
