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Updated: Jan 8, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
Oncofetal reprogramming of malignant seeds and their ecosystem: Implications in clinical research
Ankur Sharma1, Mehak Gupta2, Jacob George3
1Translational Genomics Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Kensington, NSW 2033, Australia; KK Research Centre, KK Women's and Children's Hospital, Singapore 229899, Singapore.
Abstract:
Oncofetal reprogramming, characterized by the re-expression of fetal-specific genes and proteins in cancer, signifies a key shift in tumor biology that encompasses both malignant cells and their microenvironment, forming the oncofetal ecosystem. In this commentary, we highlight recent advances in understanding oncofetal reprogramming and explore its emerging potential as a biomarker and therapeutic target in cancer research.
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