Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.4K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.6K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.6K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

424
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
424
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.2K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study.

Diabetes research and clinical practice·2012
Same author

Tight controlled expression and secretion of Lactobacillus brevis SlpA in Lactococcus lactis.

Biotechnology letters·2012
Same author

Targeting neuro-inflammatory cytokines and oxidative stress by minocycline attenuates quinolinic-acid-induced Huntington's disease-like symptoms in rats.

Neurotoxicity research·2012
Same author

Microbial keratitis in Gujarat, Western India: findings from 200 cases.

The Pan African medical journal·2012
Same author

Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities.

Organic and medicinal chemistry letters·2012
Same author

Prevalence of use of advance directives, health care proxy, legal guardian, and living will in 512 patients hospitalized in a cardiac care unit/intensive care unit in 2 community hospitals.

Archives of medical science : AMS·2012

Related Experiment Video

Updated: Jan 8, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.1K

VEGF-B: A multifaceted modulator with emerging therapeutic applications.

Chunsik Lee1, Myung-Jin Kim2, Eunyoung Jung2

  • 1Department of R&D, GEMCRO Inc, Seoul, Republic of Korea.

Pharmacological Research
|December 12, 2025
PubMed
Summary

Vascular endothelial growth factor B (VEGF-B) plays complex roles in metabolism and immunity, distinct from VEGF-A. Understanding VEGF-B

Keywords:
AngiogenesisCardiac diseaseFatty acid uptakeNeuroprotectionVEGF-B167VEGF-B186

More Related Videos

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.6K
In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

8.4K

Related Experiment Videos

Last Updated: Jan 8, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.1K
Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.6K
In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

8.4K

Area of Science:

  • Molecular Biology
  • Immunology
  • Metabolic Research

Background:

  • Vascular endothelial growth factor B (VEGF-B) is increasingly recognized for its roles beyond angiogenesis.
  • Unlike VEGF-A, VEGF-B influences tissue-specific functions like fatty acid transport, neuronal survival, and immunometabolism via VEGFR1 and NRP1.
  • VEGF-B exhibits context-dependent actions, paradoxically suppressing or promoting cancer progression and immune evasion.

Purpose of the Study:

  • To review current knowledge on VEGF-B's diverse biological functions.
  • To propose a mechanistic framework for VEGF-B signaling networks.
  • To outline strategies for developing precision therapies targeting VEGF-B in various diseases.

Main Methods:

  • Literature review of recent discoveries in VEGF-B research.
  • Analysis of VEGF-B's receptor interactions (VEGFR1, NRP1, FGFR1).
  • Integration of findings on VEGF-B's role in T cell survival and disease contexts.

Main Results:

  • VEGF-B is crucial for vascular, metabolic, and immune system interactions.
  • Recent findings highlight FGFR1 as a key receptor and VEGF-B's importance in T cell survival.
  • Clinical translation is hindered by incomplete understanding, as seen in failed diabetic kidney disease trials.

Conclusions:

  • VEGF-B is a critical regulator with paradoxical roles in health and disease.
  • Further research is needed to elucidate complex signaling and therapeutic potential.
  • Developing precision therapies requires addressing translational challenges to harness VEGF-B's benefits while maintaining homeostasis.