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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Regulation of immune factor secretion by nanofiber microstructures.

Yulian Zheng1, Maoping Li2, Yang Cao3

  • 1Department of Burn and Plastic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Acta Biomaterialia
|December 12, 2025
PubMed
Summary

Highly aligned nanofibers reprogram immune cells to reduce inflammation and promote tissue healing by modulating immune factor secretion, offering new strategies for regenerative medicine.

Keywords:
Extracellular matrixImmune cellImmune factor secretionNanofibers microstructuresTissue regeneration

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Immune factor imbalance disrupts tissue regeneration and causes chronic inflammation.
  • Nanofiber microstructures show potential for modulating immune cells in tissue regeneration.
  • Mechanisms of nanofiber influence on immune factor secretion are not well understood.

Purpose of the Study:

  • To investigate how nanofiber microstructures affect immune factor secretion.
  • To explore the potential of aligned nanofibers in promoting tissue regeneration.

Main Methods:

  • Fabrication of nanofibers with varying degrees of alignment.
  • In vitro analysis of immune factor secretion from immune cells cultured on nanofibers.
  • In vivo experiments to assess the effects of aligned nanofibers on wound healing.

Main Results:

  • Highly aligned nanofibers significantly increased anti-inflammatory factors (TGF-β1, IL-10) and decreased pro-inflammatory factors (TNF-α, IL-6).
  • These effects were mediated by immune cell adhesion receptors and mechanotransduction pathways.
  • In vivo, aligned nanofibers improved the wound immune microenvironment, promoting angiogenesis and accelerating tissue regeneration.

Conclusions:

  • Nanofiber microstructures can precisely modulate immune cell secretory function.
  • Aligned nanofibers establish a pro-regenerative immune microenvironment, enhancing tissue repair.
  • This approach offers a new paradigm for designing programmable immunoregulatory biomaterials for regenerative medicine.