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Stretch Marks: Systematic Review of its Therapeutic Approach.

J Algarra Sahuquillo1, A Martín-Gorgojo2

  • 1Servicio de Dermatología, Hospital Universitario de la Ribera, Valencia, Spain.

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Stretch mark treatments remain challenging, with topical agents like tretinoin and glycolic acid showing promise for recent marks. Combination therapies, including lasers and radiofrequency, may offer the best results for striae.

Keywords:
LaserPRPRadiofrequencyStretch marksTopicsTretinoin

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Area of Science:

  • Dermatology
  • Medical Aesthetics

Background:

  • Stretch marks (striae) are prevalent skin lesions, frequently affecting pregnant women and adolescents.
  • Despite high prevalence, effective treatment and prevention strategies for stretch marks remain a significant challenge in dermatological practice.

Purpose of the Study:

  • To systematically review the current literature on the efficacy of various treatments for stretch marks.
  • To evaluate the scientific evidence supporting different therapeutic approaches for striae.

Main Methods:

  • A systematic literature review was conducted using PubMed and LILACS databases, covering publications from 1976 to 2024.
  • Articles were assessed based on their level of scientific evidence, ranging from randomized controlled studies (Level 1) to clinical cases (Level 5).

Main Results:

  • Sixty-nine articles were analyzed, focusing on topical treatments (20), lasers and energy devices (35), and other therapies (14).
  • Tretinoin 0.1% and glycolic acid demonstrated clinical improvement, particularly for recent stretch marks.
  • Ablative/non-ablative lasers and radiofrequency with microneedles showed positive outcomes; Platelet-Rich Plasma (PRP) is beneficial as an adjunct therapy.

Conclusions:

  • Current scientific evidence is insufficient to establish a single, definitive treatment for stretch marks.
  • Many studies suffer from low quality and small sample sizes, limiting definitive conclusions.
  • Combining different treatment modalities appears to enhance overall results for stretch mark improvement.