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Methoxyflurane exposure in ambulances: a controlled laboratory study on paramedic safety
Michael A Austin1, Somalin Mao2, Jonathan MacLeod2
1Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Regional Paramedic Program for Eastern Ontario, Ottawa, Ontario, Canada; The Ottawa Hospital, Department of Emergency Medicine, Ottawa, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada.
Methoxyflurane offers rapid pain relief for trauma patients. Occupational exposure risks for paramedics are minimal, especially with ambulance ventilation, ensuring safety and effective patient care.
Area of Science:
- Occupational Health
- Anesthesiology
- Emergency Medicine
Background:
- Methoxyflurane is a self-administered anesthetic for traumatic pain.
- Paramedics may face intermittent occupational exposure to methoxyflurane.
- Assessing these risks is crucial for paramedic safety and patient care standards.
Purpose of the Study:
- To evaluate occupational exposure risks of methoxyflurane for paramedics.
- To determine the impact of ventilation on methoxyflurane exposure levels in ambulances.
- To ensure adherence to safety standards and enhance paramedic health.
Main Methods:
- Active air sampling in ambulance driver and patient compartments under controlled conditions.
- Measurements taken with and without ventilation, adhering to EPA and ISO standards.
- Exposure concentrations adjusted for time-weighted average (TWA) and compared to occupational limits.
Main Results:
- All methoxyflurane exposure concentrations remained below established 8-h TWA and NIOSH 60-min limits.
- Ventilation significantly reduced 8-h TWA exposure levels in both driver and patient compartments.
- Worst-case scenario TWA levels, even without ventilation, were below critical thresholds for paramedic safety.
Conclusions:
- Methoxyflurane can be used safely in ambulances with exposure levels well below safety thresholds.
- Ventilation is a key factor in minimizing potential methoxyflurane exposure risks for paramedics.
- The study confirms the viability of methoxyflurane for pain management without compromising paramedic safety.

