Divergent Total Synthesis of Diterpenoid Natural Products from Salvia miltiorrhiza

Herein we report a divergent strategy culminating in the first total synthesis of five terpene natural products isolated from Salvia miltiorrhiza. This approach features efficient construction of a functionalized tetralin core, a scalable route to a furan coupling partner, and a direct C-H borylation. An operationally simple HFIP-mediated benzylic C-H lactonization allowed late-stage diversification through Pd-catalyzed carbonylation and biaryl coupling, providing concise access to multiple natural products from a common intermediate.