Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CRISPR01:59

CRISPR

57.4K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
57.4K
What is Genetic Engineering?00:49

What is Genetic Engineering?

79.5K
Overview
79.5K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

1.6K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
1.6K
CRISPR and crRNAs02:53

CRISPR and crRNAs

18.7K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
18.7K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

16.0K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

Arrayed dual-gRNA CRISPR screening platform for <i>C9orf72</i> repeat expansion excision in patient iPSCs.

Molecular therapy. Advances·2026
Same author

Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.

bioRxiv : the preprint server for biology·2026
Same author

Novel Missense Variants in <i>TRIM37</i> Associated with Mulibrey Nanism and Complex Congenital Heart Disease.

Cardiology and cardiovascular medicine·2026
Same author

Interventional genomics: Bridging germline diagnosis and therapeutic action.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Microfluidic capillary transit velocity as a functional measure for sickle cell disease and <i>in vitro</i>-derived red blood cells.

Lab on a chip·2026

Related Experiment Video

Updated: Jan 8, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.3K

A Primer on Gene Editing: What Does It Mean for Pathologists?

Allison Cushman-Vokoun, Ryan J Schmidt, Matthew Charles Hiemenz

    Archives of Pathology & Laboratory Medicine
    |December 12, 2025
    PubMed
    Summary

    Gene editing therapies offer transformative potential for diseases but require pathologist involvement. Understanding gene editing technologies is crucial for pathology practice and diagnostics.

    More Related Videos

    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
    09:37

    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

    Published on: March 5, 2017

    13.5K
    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
    08:20

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

    Published on: September 2, 2021

    4.5K

    Related Experiment Videos

    Last Updated: Jan 8, 2026

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing
    08:23

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing

    Published on: November 1, 2024

    1.3K
    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
    09:37

    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

    Published on: March 5, 2017

    13.5K
    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
    08:20

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

    Published on: September 2, 2021

    4.5K

    Area of Science:

    • Biotechnology and Genomics
    • Molecular Medicine
    • Therapeutic Development

    Background:

    • Gene editing technologies are advancing rapidly, with applications emerging in oncology, inherited diseases, and infectious diseases.
    • These novel therapies, while promising, present significant considerations including risks, costs, and ethical implications.

    Purpose of the Study:

    • To educate pathologists on gene editing technologies, their indications, and associated risks.
    • To outline regulatory and practical issues impacting hospital-based practice and laboratory testing.
    • To advocate for pathologist engagement in discussions concerning gene editing therapies.

    Main Methods:

    • Convening of a Gene Editing Workgroup comprising pathologists from diverse backgrounds.
    • Facilitation by the College of American Pathologists Personalized Health Care Committee.
    • Literature review and multiple workgroup discussions to identify knowledge gaps and relevant topics.

    Main Results:

    • Identified potential gaps in pathologists' understanding of gene editing technologies.
    • Summarized key topics impacting pathology and laboratory medicine related to gene editing.
    • Highlighted the need for pathologists to be stakeholders in therapy administration, monitoring, and diagnostics.

    Conclusions:

    • Gene editing therapy is a complex and transformative medical field.
    • This article provides an introductory overview for pathologists.
    • Pathologists are encouraged to engage in discussions and adapt practices related to gene editing.