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Application of Acellular Dermal Matrix With or Without Flap Repair in Postoperative Defect Repair of Hypopharyngeal
1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background:
The reconstruction of hypopharyngeal tumor defect after tumorectomy is essential. Artificial materials play an important role in the case of extensive defects and a relative lack of healthy tissue. This study aims to investigate the role of acellular dermal matrix (ADM) in repairing defects following hypopharyngeal carcinoma resection.
Methods:
A retrospective analysis was conducted on 280 patients with hypopharyngeal carcinoma. 143 patients accepted ADM-assisted reconstruction while 137 patients didn't. Data on postoperative deglutition function, respiratory function, and complications were collected and analyzed.
Results:
No immune rejection response was observed. In partial laryngectomy, ADM significantly induces the time for hospitalization, decannulation, and oral food intake compared to the control group (p < 0.05). In total laryngectomy, ADM has advantages in terms of the number of individuals with good deglutition function (p < 0.05). There is no significant difference in pharyngocutaneous fistula.
Conclusions:
ADM is a promising biomaterial for reconstruction in hypopharyngeal carcinoma. It offers advantages such as a high success rate, good graft survival, accessibility, minimal immunogenicity, and simplified surgical procedures.
