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Updated: Jan 8, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
STAT4 gene polymorphism promotes progression of rheumatoid arthritis
Dawood Ali Salim Dawood1, Anwar Madlool Al-Janabi2, Rana Talib Al-Muswie3
1Department of Pathology and Forensic Medicine, College of Medicine, Wasit University, Kut 52001, Iraq.
Background:
Rheumatoid Arthritis (RA) is a chronic autoimmune disease. Right now, different genes play a crucial role in disease development. The objective was to assess the correlation between STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) and susceptibility to RA progression in Iraqi population.
Methods:
Three Hundred Twenty-five RA patients and Three Hundred Twenty-five matched controls were enrolled in this study. The genotyping for SNPs was performed using (Tetra-ARMS) technique. The clinical parameters were obtained through laboratory investigations and clinical examination.
Results:
Our results showed obvious statistical significance between cases and control genotypes regarding to SNPs (rs11889341: CC and TT, rs10181656: GG and rs7574865: TT). Additionally, analysis displayed a discrepancy in genotypes frequency of SNPs (rs11889341: CC among family history and Anti-CCP, but TT genotype with RF), (rs7574865: TT within RF and Anti-CCP, GG genotype in relation to family history.
Conclusion:
Our study concluded that STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) were associated with RA development in Iraqi population. Furthermore, the SNPs (rs11889341 and rs7574865) were related to family history, RF and Anti-CCP, while SNP (rs10181656) didn't display any relation among studied population.
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