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Spot On? Moving Forward IFN-γ ELISpot as a Causality Tool for Severe Delayed Hypersensitivity Reactions in Persons

Tukisa D Smith1, Jason A Trubiano2

  • 1Division of Allergy and Immunology, Department of Medicine, University of California San, Diego, La Jolla, Calif.

The Journal of Allergy and Clinical Immunology. in Practice
|December 12, 2025
PubMed
Abstract

No abstract available in PubMed .

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Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...