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Published on: February 4, 2021
Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma
Ajit K Tharakan1, Adam Hoffhines2, Laura Brett3
1Oklahoma Heart Institute, Tulsa, Oklahoma, USA.
Background:
Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare disorder, but its role in transcatheter valve failure is unknown. This report describes the first documented case of FA-LBCL in a transcatheter aortic valve.
First-In-Human/Early Reports Summary:
A 62-year-old man with a prior transcatheter aortic valve replacement presented with symptomatic severe aortic stenosis. Histopathologic analysis of the explanted valve revealed FA-LBCL as the primary cause of valve failure.
Discussion:
This case established a neoplastic process as a cause of structural valve degeneration (SVD) in transcatheter valves. It highlights that FA-LBCL should be included in the differential diagnosis of transcatheter aortic valve replacement failure, for which surgical explantation can be both diagnostic and curative.
Novelty:
This is the first report that documents FA-LBCL causing SVD of a transcatheter bioprosthetic valve.
Take-Home Messages:
FA-LBCL represents a cause of SVD in transcatheter bioprosthetic valves. This diagnosis should be considered in cases of premature valve failure.
