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Updated: Jan 8, 2026
State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Internal Cerebral Vein Doppler Velocities Reflect Maturational Changes and Hemorrhage Risk in Preterm Infants
Fleur A Camfferman1, Paul Govaert2, Floris Groenendaal3
1From the Department of Neonatology (F.A.C., F.C.), Universitair Ziekenhuis Brussel, Brussels, Belgium.
Background And Purpose:
Preterm infants are at risk of brain injury due to immature cerebral autoregulation. However, reliable assessment of cerebral perfusion remains difficult: Advanced imaging is rarely feasible at the bedside, and surrogate markers such as blood pressure or oxygen saturation correlate poorly with actual CBF. This study aimed to evaluate the velocity and waveform characteristics in the internal cerebral veins (ICVs) of preterm infants born before 32 weeks and to explore the relationship among these velocities, clinical parameters, and term-equivalent MRI.
Materials And Methods:
Prospectively, a cohort of 47 preterm infants (postmenstrual age, 28.9 [SD, 2.2] weeks, birth weight 1304 [SD, 386] g) admitted to the neonatal intensive care unit at the University Hospital Brussels was studied. ICV velocities were measured at multiple time points using Doppler ultrasound as a noninvasive marker of cerebral hemodynamics. Mixed-model analysis compared ICV velocities with clinical and term-equivalent MRI results.
Results:
ICV velocity/weight at scanning was significantly associated with postmenstrual age (P < .001), postnatal age and postnatal age squared (both P < .001), intraventricular hemorrhage (IVH) during admission (P = .003), and the interaction between gestational age and IVH (P = .005), reflecting developmental changes in cerebral circulation. IVH was observed in 5 infants. ICV velocity/weight was 1 cm/s/kg higher with IVH at 25 weeks' gestational age, decreasing to -0.1 cm/s/kg with IVH at 29 weeks' gestational age. Although the number of IVH cases was limited, these findings suggest that ICV velocity monitoring may provide useful information regarding IVH risk.
Conclusions:
ICV velocity in preterm infants reflects cerebral maturation. Infants developing IVH showed significantly higher venous velocities, corrected for body weight. Despite limited case numbers, these findings indicate that ICV velocity monitoring could serve as an early marker of hemorrhage risk. Larger studies are needed to confirm its predictive value and explore potential neuroprotective strategies.
