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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: May 2, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Toxicity Comparison between a Four-Week Moderate Hypofractionation and a Six-Week Conventional Fractionation in the

Ha Un Kim1, Jaeha Lee1, Yoon Young Jo2

  • 1Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea.

Clinical Genitourinary Cancer
|December 12, 2025
PubMed
Summary

Four-week hypofractionated radiotherapy (HFRT) shows comparable long-term toxicity to six-week conventional radiotherapy (CFRT) in salvage radiotherapy for prostate cancer patients. Both treatments demonstrated favorable genitourinary and gastrointestinal outcomes up to two years post-treatment.

Keywords:
HypofractionationProstate cancerRadiotherapySalvage

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Last Updated: May 2, 2026

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Area of Science:

  • Oncology
  • Radiation Oncology

Background:

  • Salvage radiotherapy (SRT) is used for prostate cancer recurrence after radical prostatectomy.
  • Toxicity profiles of different radiotherapy fractionation schedules require comparison.

Purpose of the Study:

  • To compare the toxicity profiles of moderate hypofractionated radiotherapy (HFRT) and conventional radiotherapy (CFRT) in patients undergoing SRT for prostate cancer.

Main Methods:

  • Retrospective review of prostate cancer patients undergoing SRT between 2022-2023.
  • Analysis of two groups: CFRT (66 Gy/30 fractions) and HFRT (55 Gy/20 fractions).
  • Propensity score matching used to control for variables influencing toxicity; primary endpoint was acute and late GU/GI toxicity up to 2 years.

Main Results:

  • 112 patients (56 per group) analyzed after matching, with median follow-up up to 27.8 months.
  • Comparable GU toxicities at 3 months and long-term (1-2 years), with transient grade 1 urgency more frequent in CFRT.
  • No significant differences in GI toxicities, including grade 3 rectal bleeding, with transient grade 2 diarrhea more frequent in CFRT.

Conclusions:

  • Four-week HFRT for SRT demonstrates favorable and comparable long-term toxicity outcomes to six-week CFRT.
  • HFRT offers a potentially effective and well-tolerated alternative for salvage treatment in prostate cancer.