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Updated: Jan 8, 2026

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On the Variation of Structural Divergence Among Residues in Enzyme Evolution.

Julian Echave1, Mathilde Carpentier2

  • 1Instituto de Ciencias Físicas (ICIFI-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina.

Proteins
|December 12, 2025
PubMed
Summary

Protein structural divergence varies with residue flexibility and distance from the active site. This variation is shaped by both non-functional and functional evolutionary constraints, challenging previous assumptions about enzyme evolution.

Keywords:
active site conservationenzyme structural evolutionevolutionary constraintsevolution‐dynamics relationshipresidue‐specific divergencestructure–function relationship

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