Raney Nickel Catalyzed Highly Chemoselective Hydrogenation for Synthesis of Tetrahydroquinolines and Indolines in
Yang Chen1, Eman Fayad2, Dalal Nasser Binjawhar3
1School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Abstract:
The selective hydrogenation of privileged heterocycles with earth-abundant metal catalysts remains a significant yet practically important challenge in heterogeneous catalysis. Herein, we report a simple and efficient Raney nickel-catalyzed protocol for the selective hydrogenation of quinolines and indoles, delivering isolated yields of up to 99%. The practical utility of the method was further demonstrated through successful gram-scale transformations, and its use of a green solvent, an inexpensive catalyst, and operationally simple conditions affords a robust and sustainable approach for scalable heterocycle hydrogenation.
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