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Advanced Multi-Level Bidirectional Attention Network for Retinal Vessel Segmentation
Zhendi Ma1, Xiaobo Li2, Yuxin Zhao1
1School of Computer Science and Technology, Zhejiang Normal University, Jinhua, 321004, China.
Interdisciplinary Sciences, Computational Life Sciences
|December 12, 2025
Summary
This study introduces a novel network for retinal vessel segmentation, significantly improving accuracy in detecting fine vessels and pathological features. The enhanced model addresses feature loss and context fusion issues, outperforming existing methods in clinical image analysis.
Area of Science:
- Medical Imaging
- Computer Vision
- Biomedical Engineering
Background:
- Retinal vessel segmentation is vital for diagnosing eye conditions using fundus images.
- Existing neural networks struggle with feature loss and context fusion, especially with complex vessel structures and varying image brightness.
- Pathological image segmentation is challenging due to fine vessel curvature and background noise.
Purpose of the Study:
- To propose a novel multi-level bidirectional attention aggregation network for improved retinal vessel segmentation.
- To address feature loss in encoders and insufficient context fusion in skip connections.
- To enhance the segmentation of fine vessels and pathological features in retinal images.
Main Methods:
- Developed a Partial Encoder Block (PEB) to minimize feature loss during encoding.
- Introduced a Dynamic Direction Attention Module (DDAM) in skip connections for better anisotropic geometric representation and detail preservation.
- Implemented a Multi-Feature Fusion Module (MFFM) to integrate multi-level features, enhancing detail retention and noise suppression.
Main Results:
- The proposed network demonstrated significant improvements across multiple datasets (DRIVE, STARE, CHASEDB1).
- Achieved notable gains in AUC, F1-score, Sensitivity, and Specificity compared to existing methods.
- Specifically, DRIVE dataset saw improvements of 0.19% (AUC), 0.43% (F1), and 1.17% (Sensitivity).
Conclusions:
- The multi-level bidirectional attention aggregation network effectively enhances retinal vessel segmentation.
- The proposed modules (PEB, DDAM, MFFM) successfully address limitations of previous methods.
- The network shows superior performance in segmenting fine vessels and pathological features in retinal fundus images.

