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Published on: February 26, 2013
Association between systemic inflammation and risk of atrial fibrillation in cancer survivors: a population-based
Quan Yang1,2, Jiazhen Zheng3, Chunting Zhao1,2
1Division of Cardiovascular Medicine,Cardiac and Vascular Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Background:
Cancer survivors (CSs) are at increased risk of atrial fibrillation (AF), potentially due to cancer-related inflammation and treatment effects. While inflammation has been implicated in both cancer and AF, the association between C-reactive protein (CRP) and AF risk in CSs remains unclear.
Methods:
We analyzed data from 19,677 UK Biobank participants (mean age 60; 34.2% male) with a prior cancer diagnosis. Incident AF was evaluated using competing-risk Cox proportional hazards models, adjusting for sociodemographic, lifestyle, and clinical factors.
Results:
Over a median follow-up of 10.4 years, 836 CSs (4.2%) developed AF. Competing risk analysis revealed that the significant association between elevated CRP (> 2 mg/L) and AF risk in CSs, observed in models adjusted for sociodemographic and clinical factors (HR 1.21, 95% CI 1.06-1.37; P = 0.005), progressively attenuated with further adjustment for lifestyle factors (HR 1.14, 95% CI 0.99-1.31; P = 0.076). Despite losing statistical significance in the fully adjusted model, a consistent, suggestive trend was observed. This association was particularly pronounced in individuals not receiving radiotherapy.
Conclusions:
Our findings suggest that systemic inflammation is associated with an increased risk of AF among CSs, particularly in individuals without a history of radiotherapy. Further studies are needed to explore underlying mechanisms and therapeutic implications.
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