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Updated: Jan 8, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Highly Efficient Organocatalytic House-Meinwald Rearrangement for the Facile Synthesis of Aldehydes: Swift Access to
Friedemann Dressler1, Ihssane El Fdali2, Luisa L Ciezarek1
1Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany.
Abstract:
We present a new organocatalytic method for synthesizing aldehydes under mild conditions using readily accessible terminal epoxides as starting materials and bis(trifluoromethane)sulfonimide (Tf2NH) as the catalyst. We identified intermediate aldehyde dimerization products at lower temperatures and observed their cleavage at 55°C. We isolated the products in yields of 89-97% using catalyst loadings as low as 0.5 mol%. To underline the applicability of our new approach, we synthesized ibuprofen in a three-step process and overall yield of 90%.
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