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  3. Age-dependent Recovery Of White Matter Integrity After Surgical Correction In Children With Infantile Esotropia.
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  3. Age-dependent Recovery Of White Matter Integrity After Surgical Correction In Children With Infantile Esotropia.

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Age-dependent recovery of white matter integrity after surgical correction in children with infantile esotropia.

Yue Zhang1,2,3,4, Yue Wang1,2,3,4, Jianlin Guo5

  • 1Medical School, Faculty of Medicine, Tianjin University, Tianjin, China.

BMC Neurology
|December 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Surgical correction of infantile esotropia (IE) aids white matter recovery. Younger children experience faster microstructural repair, highlighting an optimal therapeutic window for improved neurodevelopmental outcomes.

Keywords:
Diffusion tensor imagingInfantile esotropiaNeurodevelopmentSurgical interventionWhite matter integrity

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Area of Science:

  • Pediatric neurosurgery
  • Neurodevelopmental imaging
  • Ophthalmology

Background:

  • Infantile esotropia (IE) can impede white matter maturation during critical early brain development.
  • Surgical correction of IE aims to restore ocular alignment and may influence neurodevelopment.
  • The impact of age on white matter recovery post-IE surgery is not well understood.

Purpose of the Study:

  • To investigate how age affects white matter rehabilitation after surgery in children with IE.
  • To identify the optimal age for surgical intervention to maximize neurodevelopmental and clinical outcomes.

Main Methods:

  • Utilized Diffusion Tensor Imaging (DTI) to assess white matter integrity (fractional anisotropy and mean diffusivity) in children with IE and controls.
  • Employed automated fiber quantification to analyze microstructural properties of 20 major white matter tracts.
  • Conducted cross-sectional and longitudinal analyses to compare developmental trajectories.

Main Results:

  • Preoperatively, IE patients showed elevated mean diffusivity in several white matter tracts.
  • Post-surgery, mean diffusivity significantly decreased, while fractional anisotropy changes were less pronounced.
  • Longitudinal data indicated that surgery accelerated white matter microstructure growth, especially in younger children.

Conclusions:

  • Surgical correction of IE promotes white matter restoration through mechanisms that complement typical neurodevelopment.
  • Earlier surgical intervention is linked to faster microstructural recovery, suggesting a sensitive period for maximizing repair.
  • Optimizing the timing of surgery can enhance both white matter repair and overall functional outcomes.