Related Experiment Video

Updated: Jan 8, 2026

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.7K

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that

Laura Caceres-Palomo1, Elisabeth Sanchez-Mejias1,2, Laura Trujillo-Estrada1,2

  • 1Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain.

Journal of Neuroinflammation
|December 13, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
APOEAlzheimer´s diseaseAstrocytesCellular modelGlial dysfunctionNeurodegenerationNeuroinflammationSenescenceStem cells

More Related Videos

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.5K
Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
10:59

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

Published on: June 6, 2025

1.0K

Related Experiment Videos

Last Updated: Jan 8, 2026

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.7K
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.5K
Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
10:59

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

Published on: June 6, 2025

1.0K

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

Articles linked to this work by shared authors, journal, and citation graph.

Mutational constraints on RSV F and its neutralization by antibodies.

Nature·2026

Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization.

Bioactive materials·2026

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model.

bioRxiv : the preprint server for biology·2026

Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants.

Nature immunology·2026

Development of a thin-layer chromatography-angiotensin-converting enzyme bioassay coupled with digital image analysis for effect-directed screening of enzyme inhibitors.

Journal of chromatography. A·2026

Amylin at the crossroads of type 2 diabetes and neurodegenerative diseases.

Ageing research reviews·2026

Aging-enhanced accumulation of fibroblasts excludes oligodendrocytes in demyelinated lesions.

Journal of neuroinflammation·2026

Antigen-specific CD8 T cells accumulate and functionally reactivate in the bone marrow following brain infection.

Journal of neuroinflammation·2026

SPRY1 suppresses microglial fatty acid oxidation by retaining FATP3 on the endoplasmic reticulum in Alzheimer's disease.

Journal of neuroinflammation·2026

The influence of anti-CD20-directed B cell depletion across different agents on Epstein-Barr virus-specific humoral and cellular immunity in patients with multiple sclerosis.

Journal of neuroinflammation·2026

Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer-treated rats.

Journal of neuroinflammation·2026

Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.

Journal of neuroinflammation·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us