Bisphenol exposure in preterm neonates: a cohort study with measurements at admission and discharge in a neonatal intensive care unit in Ankara, Türkiye
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View abstract on PubMed
Summary
This summary is machine-generated.Bisphenol A (BPA) and bisphenol F (BPF) exposure in preterm infants and mothers was assessed. Higher maternal BPF was linked to lower birth weight, and cord BPA correlated with reduced penile length, indicating potential health risks.
Area Of Science
- Environmental Health
- Neonatology
- Toxicology
Background
- Preterm infants in neonatal intensive care units (NICUs) may face unique exposure risks.
- Bisphenol compounds, such as Bisphenol A (BPA) and Bisphenol F (BPF), are common environmental contaminants.
- Understanding exposure levels and associations in vulnerable neonatal populations is crucial.
Purpose Of The Study
- To assess Bisphenol A (BPA) and Bisphenol F (BPF) exposure in preterm infants and their mothers.
- To investigate associations between prenatal and neonatal bisphenol exposure and infant health outcomes.
- To explore potential sources of exposure within the NICU environment.
Main Methods
- Collected maternal urine, cord blood, and infant urine samples from 58 preterm infants and 48 mothers.
- Quantified BPA and BPF levels using high-performance liquid chromatography (HPLC).
- Analyzed correlations between bisphenol levels and birth weight percentile, stretched penile length, and birth order.
Main Results
- Maternal urinary BPF negatively associated with newborn birth weight percentile.
- Infant urinary BPA levels showed positive correlation between first and last day samples.
- Cord BPA levels negatively associated with stretched penile length.
- First-born infants had higher urinary BPF levels; males showed distinct BPF patterns.
- No significant correlation found between neonatal BPA/BPF and maternal/cord levels or NICU procedures.
Conclusions
- Neonatal bisphenol exposure is present and may be linked to adverse outcomes like reduced birth weight and penile length.
- Exposure sources for neonates in the NICU may be unpredictable and not fully captured by maternal or cord samples.
- Minimizing BPA and BPF exposure during pregnancy and NICU stays is essential for protecting infant health.
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