Related Experiment Video
Updated: Jan 8, 2026
09:27
Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
Published on: April 22, 2016
18.0K
Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts
Si Liu1,2, Peiji Deng1,2, Qianfan Chen1,2,3
1School of Chemical Engineering, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 13, 2025
Summary
Reticular materials like MOFs, COFs, and HOFs offer enzyme immobilization but often reduce performance. Strategies focus on material tuning, interface design, and protein engineering to enhance biocatalyst activity.
Area of Science:
- Materials Science
- Biochemistry
- Nanotechnology
Background:
- Reticular materials (MOFs, COFs, HOFs) are promising for enzyme immobilization due to their properties.
- Enzyme performance is often reduced by encapsulation due to confinement and altered microenvironments.
Purpose of the Study:
- To review strategies for enhancing enzyme activity within reticular materials.
- To provide a multiscale perspective on improving enzyme encapsulation.
Main Methods:
- Summarizing approaches from nano/macro material tuning, molecular interface design, and protein surface engineering.
- Highlighting differences in enzyme activity enhancement across MOF-, COF-, and HOF-based composites.
- Discussing nano-bio effects for customized biocatalytic functions.
Main Results:
- Multiscale strategies can significantly boost enzyme performance in reticular materials.
- Nano-bio effects enable the creation of nanobiohybrids with novel biocatalytic functions.
- Differences exist in activity enhancement among MOF, COF, and HOF systems.
Conclusions:
- Understanding molecular events is key to optimizing enzyme-framework interactions.
- Advanced designs in heterogeneous biocatalysts are emerging from reticular chemistry.
- Challenges and opportunities exist for translating these advancements into practical applications.
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